Antibiotic Sinus Treatment: What Works and When

Got a stuffy nose that won’t quit? A sinus infection can feel like a pressure cooker in your face, and many wonder if an antibiotic will fix it. The truth is, antibiotics help only when bacteria are the culprit. If a virus is causing the misery, rest and a good decongestant are usually enough.

When Doctors Recommend Antibiotics

Doctors look for three red flags before prescribing an antibiotic: fever above 101°F (38.3°C), facial pain that gets worse when you lean forward, and symptoms that have lasted more than 10 days without improvement. If you check any of those boxes, a bacterial infection is likely, and an antibiotic can speed up recovery.

Even then, the choice of drug matters. Some antibiotics hit the sinus bacteria dead‑on, while others are better for ear infections or pneumonia. That’s why you’ll often hear names like amoxicillin, doxycycline, or azithromycin tossed around.

Common Antibiotics for Sinus Infections

Amoxicillin is the go‑to first‑line treatment. It’s cheap, safe for most adults, and works well against the usual sinus bacteria. If you’re allergic to penicillin, doctors might switch to Doxycycline, which also covers atypical germs.

Azithromycin DT (the chewable tablet) is popular for kids because it’s easy to take and needs a short 5‑day course. It’s a solid backup if amoxicillin doesn’t clear the infection or if you’re dealing with a resistant strain.

When bacteria are resistant or the infection is severe, a second‑line drug like Levofloxacin may be needed. These are stronger, have more side effects, and are reserved for cases that don’t respond to first‑line meds.

Take the antibiotic exactly as prescribed—finish the whole course even if you feel better after a couple of days. Stopping early can let the bacteria bounce back, and it fuels antibiotic resistance.

While you’re on the meds, keep your sinuses moist. Use a saline spray, drink plenty of water, and consider a humidifier at night. Over‑the‑counter pain relievers (ibuprofen or acetaminophen) can cut the ache and bring your temperature down.

What about side effects? Most people tolerate these drugs well, but you might notice mild stomach upset, a brief rash, or a metallic taste. If you develop severe diarrhea, high fever, or a rash that spreads, call your doctor right away.

Finally, remember that antibiotics aren’t a cure‑all. If you’ve had multiple sinus infections in a short period, ask your doctor about imaging or a referral to an ENT specialist. Sometimes structural issues, like a deviated septum, keep the sinuses clogged and prone to infection.

Bottom line: antibiotics help when a bacterial sinus infection is confirmed, and the right drug can shave days off your misery. Use them wisely, finish the course, and pair them with supportive care for the fastest relief.